Benzodiazepines

Benzodiazepines such as Diazepam and Midazolam are psychoactive agents. Benzodiazepines are commonly administered either nasally, orally or intravenously. They are used extensively as anxiolytics, anti convulsants, hypnotics and muscle relaxants. Diazepam binds with a high affinity to the gamma amino butyric acid (GABA) a receptor in the brain thus reducing arousal and affecting emotions. Their use can result in drowsiness, confusion and insomnia. Psychological and physical dependence on benzodiazepines can develop if high doses of the drug are given over a prolonged period. Only trace amounts (less than 1%) of most benzodiazepines are excreted unaltered in the urine. The drug has a half - life of 40 to 100 hours. This Test detects the presence of benzodiazepines in human urine specimens, qualitatively.